Follicle development and their sizes
Primordial Dormant, small, only one layer of flat granulosa cells Primordial follicles are about 0.03-0.05 mm in diameter.
Primary Mitotic cells, cuboidal granulosa cells Almost 0.1 mm in diameter
Secondary Presence of theca cells, multiple layers of granulosa cells The follicle is now 0.2 mm in diameter
Early tertiary The early tertiary follicle is arbitrarily divided into five classes. Class 1 follicles are 0.2 mm in diameter, class 2 about 0.4 mm, class 3 about 0.9 mm, class 4 about 2 mm, and class 5 about 5 mm.
Late tertiary Fully formed antrum, no further cytodifferentiation, no novel progress Class 6 follicles are about 10 mm in diameter, class 7 about 16 mm, and class 8 about 20 mm. It is common for non-dominant follicles to grow beyond class 5, but rarely is there more than one class 8 follicle.
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